Patient portrayal.

You’re committed to managing your diabetes.

Lilly is committed to ensuring you can afford your Lilly insulin.

That's why we offer a portfolio of lower list-priced* insulins.

Lilly's Non‑Branded Insulin Options

Click on each of the images below to learn more about each of the non-branded insulin options offered by Lilly.

Insulin Lispro Injection U-100

Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25^™ KwikPen^®

Insulin Lispro Injection Junior KwikPen^®

Lilly's Portfolio of Non‑Branded Insulins may help to reduce your out‑of‑pocket costs^*

Insulin Lispro Injection U-100 vial is $25. The lowest list-priced mealtime insulin available.

When you pick up your insulin prescription, your pharmacist can help determine your least expensive option.

^*Important: For many people with commercial drug insurance, Lilly's Humalog branded insulin may still have a lower out-of-pocket cost than Lilly's Non-Branded Insulins.

^*You should consider formulary status of all medications you may be taking when making enrollment decisions.

What to know about Lilly's Portfolio of Non‑Branded Insulins

Insulin Lispro is Humalog^® (insulin lispro). It can help control blood sugar spikes that happen after a meal.

Same insulin as Humalog U-100 available under a different label in the same KwikPen and vial made by the same manufacturer.

Learn more about this insulin

Humalog and Insulin Lispro Injection are used to treat people with diabetes for the control of high blood sugar.

SELECT SAFETY INFORMATION

Warning - Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Because it’s the same molecule as Humalog^® (insulin lispro), Lilly's Insulin Lispro Injection U-100 helps control the blood sugar spikes that happen naturally when you eat. Lilly's Insulin Lispro Injection U-100 (a fast-acting insulin) works to manage those blood sugar spikes and may help keep your sugar levels in balance. Lilly's Insulin Lispro Injection U-100 is taken within 15 minutes before eating or right after eating a meal.

Insulin Lispro Injection is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day. It's important to talk to your doctor about when and how often you should check your blood sugar levels.

SELECT SAFETY INFORMATION

Warning - Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3 mL cartridges
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

The Insulin Lispro Injection U-100 KwikPen is a small, lightweight pen that's prefilled with mealtime insulin. Since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in a purse or slip it into a jacket or coat pocket. It's a good idea to always carry an extra pen.

For complete Instructions for Use of the Insulin Lispro Injection U-100 KwikPen, click here.

^*Once you start using Insulin Lispro Injection U-100 KwikPen, it should be stored at room temperature, below 86^˚F (30^˚C), and must be used within 28 days or be discarded, even if it still contains Insulin Lispro Injection U-100.

SELECT SAFETY INFORMATION

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. Do not inject your insulin into the exact same spot or where the skin has pit or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

Lilly’s Insulin Lispro Injection U-100 may be injected under your skin in the stomach area, the back of your upper arms, upper legs, or buttocks (see diagram). Never inject Lilly’s Insulin Lispro Injection U-100 into a muscle or vein. Ask your doctor for help determining the most appropriate injection sites for you.

Be sure to use a different injection site each time and do not overuse any site.

SELECT SAFETY INFORMATION

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Where to inject insulin lispro. Injection sites include the stomach area, buttocks, upper legs, and upper arms.

Everyone’s experience with mealtime insulin is different, but there are some things you can look out for.

Dose changes

Your Insulin Lispro Injection U-100 dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their dose over time.

Blood sugar variations

When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal.

Changes are normal

Your blood sugar varies based on stress, what you eat, other medications, exercise, and other factors. Don’t be discouraged by changes in your blood sugar. With your doctor’s input, these variations may provide learning opportunities.

SELECT SAFETY INFORMATION

Warning - Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

Low blood sugar. This can cause:
- dizziness or light-headedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger

If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon rescue medication. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.

Insulin Lispro Protamine and Insulin Lispro Mix75/25 is Humalog^® Mix 75/25™. It can help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

Same insulin as Humalog Mix75/25 available under a different label in the same KwikPen made by the same manufacturer.

Learn more about this insulin

Humalog Mix75/25, Humalog Mix50/50, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are used to treat adults with diabetes for the control of high blood sugar.

SELECT SAFETY INFORMATION

Warning

Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 is a combination of fast- and longer-acting insulins that work together to help manage your blood sugar between meals and at night, as well as blood sugar spikes that can happen when you eat.

Note that Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 starts working faster than other insulins that contain regular human insulin.

It's important to take Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 within 15 minutes before eating a meal to help prevent low blood sugar.

SELECT SAFETY INFORMATION

Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Insulin mixes—such as Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen—combine fast-acting and longer-acting insulins to give you the benefit of both insulins. Mixes help manage your blood sugar between meals and at night, as well as blood sugar spikes that can happen when you eat.

Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen is a small, lightweight pen that’s prefilled with combinations of fast- and longer-acting insulin. Plus, since it shouldn't be refrigerated after the first use^*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it’s the size of a marker. It’s a good idea to always carry an extra pen. Unused pens stored at room temperature, below 86°F (30°C), should be thrown away after 10 days.

For complete Instructions for Use of the Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen, click here.

^*Once you start using Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 10 days or be discarded, even if it still contains Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25.

SELECT SAFETY INFORMATION

Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may be injected under your skin in the stomach area, the back of your upper arms, upper legs, or buttocks (see diagram). Never inject Lilly’s Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 into a muscle or vein. Ask your doctor for help determining the most appropriate injection sites for you.

Be sure to use a different injection site each time and do not overuse any site.

SELECT SAFETY INFORMATION

Everyone’s experience with combinations of fast- and longer-acting insulin is different, but there are some things you can look out for.

Dose changes

Your dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their dose over time.

Blood sugar variations

When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal.

Changes are normal

SELECT SAFETY INFORMATION

Low blood sugar. This can cause:
- dizziness or light-headedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger

The insulin in the Insulin Lispro Injection Junior KwikPen is Humalog®. This insulin helps control blood sugar "spikes" that happen after you eat.

Same insulin as Humalog Junior KwikPen available under a different label in the same KwikPen made by the same manufacturer.

Learn more about this insulin

Humalog and Insulin Lispro Injection are used to treat people with diabetes for the control of high blood sugar.

Lilly’s Insulin Lispro Injection Junior KwikPen is an insulin pen that offers the combined benefits of a prefilled disposable pen with rapid-acting insulin and half-unit dosing. Insulin Lispro Injection Junior KwikPen is different from Insulin Lispro Injection KwikPen because it can dose in half-unit increments. Plus, because it's a KwikPen, it shouldn’t be refrigerated after the first use^*, and you can take it just about anywhere. You can carry it in your purse, your child’s backpack, or a pocket because it’s the size of a marker. Remember to always carry an extra pen.

Lilly’s Insulin Lispro Injection Junior KwikPen offers fast-acting insulin, right when you need it, to help control your child’s diabetes.

After your child uses Lilly’s Insulin Lispro Injection Junior KwikPen for the first time, do not put it back in the refrigerator. Lilly’s Insulin Lispro Injection Junior KwikPen is good for 28 days after the first use. After that, it should be discarded, even if insulin remains^*. Always call to make sure your pharmacy has Lilly’s Insulin Lispro Injection Junior KwikPen (in the quantity you need) in stock. If not, they can order them for you.

^*Once you start using Insulin Lispro Injection Junior KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains Insulin Lispro Injection U-100.

SELECT SAFETY INFORMATION

Warning - Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Lilly's Insulin Lispro Injection Junior KwikPen is a small, lightweight pen that’s prefilled with mealtime insulin. After the first use^*, the pen shouldn’t be refrigerated, which makes it simple to bring it along anywhere you and your child may go. You can carry it in your purse, your child’s backpack, or slip it into a jacket or coat pocket. It’s a good idea to always carry an extra pen.

For complete Instructions for Use of the Insulin Lispro Junior KwikPen, click here.

^*Once you start using Insulin Lispro Junior KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains Insulin Lispro Injection U-100.

SELECT SAFETY INFORMATION

Warning - Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3mL cartridges
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Lilly’s Insulin Lispro Injection may be injected under your child’s skin in the stomach area, the back of their upper arms, upper legs, or buttocks (see diagram). Never inject Lilly’s Insulin Lispro Injection into your child’s muscle or vein. Ask your doctor for help in determining the most appropriate injection sites for your child.

Be sure to use a different injection site each time and do not overuse any site.

SELECT SAFETY INFORMATION

Everyone’s experience with mealtime insulin is different, but there are some things you can look out for.

Dose changes

Your child's Insulin Lispro Injection dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their dose over time.

Blood sugar variations

When you track your child's blood sugar every day, you will probably see different numbers all the time. These variations in your child's blood sugar from day to day are normal.

Changes are normal

Your child's blood sugar varies based on stress, what your child eats, other medications, exercise, and other factors. Don’t be discouraged by changes in your child's blood sugar. With your doctor’s input, these variations may provide learning opportunities.

SELECT SAFETY INFORMATION

Low blood sugar. This can cause:
- dizziness or light-headedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger

Prescribing Information

Insulin Lispro Injection Prescribing Information

Insulin Lispro Injection Patient Information

Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Prescribing Information

Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Patient Information

Instructions for Use

Insulin Lispro Injection Vial

Insulin Lispro Injection KwikPen

Insulin Lispro Injection Junior KwikPen

Insulin Lispro Protamine & Insulin Lispro Injectable Suspension Mix75/25 KwikPen

INDICATIONS

Humalog^® (HU-ma-log) and Insulin Lispro Injection are fast-acting insulins used to control high blood sugar in adults and children with diabetes.

Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.
It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Humalog^® Mix50/50^™, Humalog^®Mix75/25^™, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixed U-100 insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes.

It is not known if Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are safe and effective for children younger than 18 years of age. There were no studies done with these insulins in children younger than 18. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Insulin Lispro products are Humalog. Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 contain insulin lispro protamine mixed with insulin lispro.

SAFETY SUMMARY

Warnings -

Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3 mL cartridges
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

Low blood sugar. This can cause:
- dizziness or light-headedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon rescue medication. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
Severe allergic reaction.
Get emergency help right away if you have:
- a rash over your whole body
- sweating
- extreme drowsiness
- swelling of your face, tongue, or throat
- trouble breathing
- a faint feeling
- dizziness
- a fast heartbeat
- shortness of breath
- confusion
Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or "TZDs," with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Common side effects

The most common side effects of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are:

low blood sugar
reactions where you have injected insulin
swelling of your hands or feet
itching

allergic reactions
changes in fat tissue where you have injected insulin
weight gain
rash

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
about any other prescription medicines you take, especially ones called TZDs.
about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your insulin lispro product

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

If you are taking Humalog or Insulin Lispro Injection, inject it under your skin within 15 minutes before or right after you eat a meal.
If you are taking Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, inject it under your skin within 15 minutes before you eat a meal.

Staying safe while taking your insulin lispro product

To stay safe while taking your insulin, be sure to never inject Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 in your vein, muscle, or with an insulin pump. Also be sure not to:

mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids.
drive or use heavy machinery until you know how your insulin lispro product affects you.
drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product.

Learn more

Humalog, Humalog Mix50/50, Humalog Mix75/25, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix 75/25 are prescription medicines. For more information, call 1-800-545-5979.

This summary provides basic information about Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

HI BOI SP U100 75/25 CON BS 22NOV2023

Humalog^®, Humalog^® Mix50/50^™, and Humalog^® Mix75/25^™ are trademarks and registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

You’re committed to managing your diabetes.

Lilly is committed to ensuring you can afford your Lilly insulin.

That's why we offer a portfolio of lower list-priced* insulins.

Lilly's Non‑Branded Insulin Options

Insulin Lispro Injection U-100

Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25™ KwikPen®

Insulin Lispro Injection Junior KwikPen®

Lilly's Portfolio of Non‑Branded Insulins may help to reduce your out‑of‑pocket costs*

When you pick up your insulin prescription, your pharmacist can help determine your least expensive option.

Insulin Affordability

What to know about Lilly's Portfolio of Non‑Branded Insulins

Insulin Lispro is Humalog® (insulin lispro). It can help control blood sugar spikes that happen after a meal.

Insulin Lispro Protamine and Insulin Lispro Mix75/25 is Humalog® Mix 75/25™. It can help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

The insulin in the Insulin Lispro Injection Junior KwikPen is Humalog®. This insulin helps control blood sugar "spikes" that happen after you eat.

INDICATIONS

SAFETY SUMMARY

Warnings -

Common side effects

Before using

How to take

Learn more

Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25^™ KwikPen^®

Insulin Lispro Injection Junior KwikPen^®

Lilly's Portfolio of Non‑Branded Insulins may help to reduce your out‑of‑pocket costs^*

Insulin Lispro is Humalog^® (insulin lispro). It can help control blood sugar spikes that happen after a meal.

Insulin Lispro Protamine and Insulin Lispro Mix75/25 is Humalog^® Mix 75/25™. It can help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.